Home > Search Results: keywords:"renín-angiotenzín-aldosterónový systém"
Search:
Search Tips :: Advanced Search
Search collections:
Sort by: Display results: Output format:
National Repository of Grey Literature 2 records found  Search took 0.00 seconds. 
The role of arachidonic acid metabolites in regulation of blood pressure in experimental models of angiotensin II- dependent hypertension
 Jíchová, Šárka ; Červenka, Luděk (advisor) ; Zicha, Josef (referee) ; Štengl, Milan (referee)
Introduction: Two major product groups originate from the arachidonic acid metabolic pathway of cytochromes P450: epoxyeicosatrienoic acid (EETs) and 19 and 20-hydroxyeicosatetraenoic acid (19- and 20-HETE). These metabolites play an important role in the regulation of blood pressure, inflammatory responses, regulation of sodium excretion and other crucial physiological processes. Hypothesis: Our studies were based on the hypothesis that abnormalities in the production and function of these cytochrome P450 metabolites significantly contribute to the pathophysiology of hypertension development, in particular in the angiotensin II-dependent models. Objective: To investigate if the increased bioavailability of the above-mentioned metabolites in the kidney tissue will result in blood pressure reduction in the ANG II - dependent rat model of hypertension. Methods: The two methods to increase the concentration of EETs was chosen. In the first part of the study, we administered a soluble epoxide hydrolase inhibitor cAUCB [cis-4- [4- (3-adamantan-1-yl- ureido) cyclohexyloxy] benzoic acid, at a dose of 26 mg.l-1 administered in drinking water], an enzyme responsible for inactivation of biologically active forms of EETs. In the second series of the experiments we applied a synthetic EET analogue, called...
Detailed record
Relationship between the renin-angiotensin-aldosterone system and the heart and its influence during 5°C cold acclimation.
 Hlaváčová, Diana ; Horníková, Daniela (advisor) ; Heleš, Mário (referee)
Heart as one of the life-important organs is influenced by many ongoing processes in organism. Even the smallest molecular changes can importantly influence heart's physiology and activity. Last years, there were many studies concentrating on clarification of renin-angiotensin- aldosteron system (RAAS) and its influence on heart and kidneys. Cardiovascular diseases are usually caused by changes in RAAS and that is the reason why more and more experts are examining the extent to which diseases can be prevented and heart function improved. Ambient temperature is one of the factors that greatly affects the RAAS and the heart. In this thesis I tried to summarize current knowledge about RAAS and its effects on organism, focusing on influencing the physiology of the heart. While ambient temperature has significant effect on the RAAS and the heart, this thesis points to the knowledge associated with cold acclimation at 5 řC. Key words: renin-angiotensin-aldosteron system, heart, cold, hypertension, adrenergic receptors, natriuretic peptides
Detailed record

Interested in being notified about new results for this query?
Subscribe to the RSS feed.
Digital Repository :: Search :: Submit :: Personalize :: Help
Powered by Invenio v1.1.2
Maintained by admin.invenio@techlib.cz
This site is also available in the following languages:
Česky  English